Publications 2022-23

65. Oyaghire SN, Quijano E, Perera JDR, Mandl HK, Saltzman WM, Bahal R, Glazer PM. “DNA Recognition and Induced Genome Modification by a Hydroxymethyl-γ Tail-Clamp Peptide Nucleic Acid” . Cell Reports Physical Sciences (Accepted), 2023.

64. Gogate A, Belcourt J, Shah M, Wang A, Frankel A, Kolmel H, Chalon M, Stephen P, Kolli A, Tawfik S, Jin J, Bahal R, Rasmussen T, Manautou J, and Zhong X. “Targeting the Liver with Nucleic Acid Therapeutics for the Treatment of Systemic Diseases of Liver Origin.” Pharmacological Reviews (Accepted), 2023.

63. Dhuri K, Duran T, Chaudhuri B, Slack FJ, Vikram A, Glazer PM, Bahal R. “Head to Head comparison of in vitro and in vivo efficacy of pHLIP conjugated anti seed gamma Peptide Nucleic Acids”. Cell Reports Physical Sciences (Accepted), 2023.

62. Gaddam RR, Amalkar V, Sali VK, Nakuluri K, Jacobs JS, Kim YR, Li Q, Bahal R, Irani K, Vikram A. Role of miR-204 in segmental cardiac effects of phenylephrine and pressure overload”. Biochemical and Biophysical Research Communications (Accepted), 2023.

61. Kasina V, Wahane A, Liu CH, Yang L, Nieh MP, Slack FJ, Bahal R. “Next-generation poly-L-histidine formulations for miRNA mimic delivery. Molecular Therapy Methods & Clinical Development, 2023.

60. Pradeep SP, Malik S, Slack FJ*, Bahal R*. “Unlocking the potential of chemically modified peptide nucleic acids for RNA-based therapeutics“. RNA, 2023. *Co-corresponding authors.

59. Kumar V, Wahane A, Gupta A, Manautou JE, Bahal R. Multivalent Lactobionic acid and N-Acetylgalactosamine-conjugated Peptide Nucleic Acids for Efficient in vivo Targeting of Hepatocytes“. Advanced Healthcare Materials2023.

58. Wang Y#, Malik S#, Suh HW, Xiao Y, Deng Y, Fan R, Huttner A, Bindra RS, Singh V, Saltzman WM*, Bahal R*. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy“. Science Advances2022. #Both authors contributed equally, *co-corresponding senior authors.

57. Ahangari F, Price NL, Malik S, Chioccioli M, Bärnthaler T, Adams TS, Kim J, Pradeep SP, Ding S, Cosme Jr C, Rose K, McDonough J, Aurelien N, Ibarra G, Omote N, Schupp JC, DeIuliis G, Villalba JA, Sharma L, Ryu C, Dela Cruz C, Liu X, Prasse A, Rosas I, Bahal R, Fernandez-Hernando C, Kaminski N. “microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis“. JCI Insight, 2023.

56. Putman R, Ricciardi AS, Carufe K, Quijano E, Bahal R, Glazer PM, Saltzman MW. “Nanoparticle-mediated genome editing in single-cell embryos via peptide nucleic acids“. Bioengineering & Translational Medicine, 2022.

55. Wu H, Wahane A, Alhamadani F, Zhang K, Parikh R, Lee S, McCabe EM, Rasmussen TP, Bahal R, Zhong X, Manautou JE. Nephrotoxicity of Antisense Oligonucleotide Drugs“. Current Opinion in Toxicology, 2022.

54. Emehiser RG,  Dhuri K,  Shepard C,  Karmakar S,  Bahal R, Hrdlicka PJ. Serine-γPNA, Invader probes and chimeras thereof: Three probe chemistries enabling sequence-unrestricted recognition of double-stranded DNA“. Organic & Biomolecular Chemistry, 2022.

53. Liu A, Zhao J, Shah M, Migliorati J, Tawfik S, Bahal R, Rasmussen T, Manautou J, Zhong X. “Nedosiran, a Candidate siRNA Drug for the Treatment of Primary Hyperoxaluria: Design, Development, and Clinical Studies“. ACS Pharmacology & Translational Science, 2022. 

52. Dhuri K, Pradeep SP, Shi J, Anastasiadou E, Slack FJ, Gupta A, Zhong X, Bahal R. “Simultaneous targeting of multiple oncomiRs with phosphorothioate or PNA-based anti-miRs in lymphoma cell lines“. Pharmaceutical Research, 2022.

51. Zhang X, Rotllan N, CanfránDuque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. “Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression“. Circulation Research, 2022.

50. Edalatian Zakeri S#, Pradeep SP#, Kasina K#, Laddha AP, Manautou JE, Bahal R. “Casimersen for the treatment of Duchenne Muscular Dystrophy“. Trends in Pharmacological Sciences, 2022. #authors contributed equally.

49. Jin Y, Edalatian Zakeri S, Bahal R, Wiemer AJ.New Technologies Bloom Together for Bettering Cancer Drug Conjugates“. Pharmacological Reviews, 2022.

48. Kasina V, Mownn RJ, Bahal R, Sartor GC. Nanoparticle delivery systems for substance use disorder.Neuropsychopharmacology, 2022.

47. Migliorati J, Liu S, Liu A, Gogate A, Nair S, Bahal R, Rasmussen T, Manautou J, Zhong X.Absorption, distribution, metabolism, and excretion of FDA-approved antisense oligonucleotide drugs.Drug Metabolism and Disposition, 2022.

46. Alhamadani F, Zhang K, Parikh R, Wu H, Rasmussen T, Bahal R, Zhong X, Manautou J. Adverse Drug Reactions and Toxicity of the FDA-approved Antisense Oligonucleotide Drugs. Drug Metabolism and Disposition, 2022.

45. Dhuri K#, Gaddam R#, Kim YR, Jacobs J, Kumar V, Li Q, Irani K, Bahal R*, Vikram A*. γ peptide nucleic acid-based miR-122 inhibition rescues vascular endothelial dysfunction in mice fed a high-fat diet. Journal of Medicinal Chemistry, 2022. #Both authors contributed equally, *co-corresponding senior authors