Publications

2019

30. Chen L, Wang P, Bahal R, Manautou JE, Zhong X-b. “Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver.” PLoS ONE, 2019. 

29. Svoronos AA, Bahal R, Pereira MC, Barrera FN, Deacon JC, Bosenberg M, DiMaio D, Glazer PM, and Engelman DM. “Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide.” Molecular Pharmaceutics, 2019.

28. Sahraei M, Chaube B,  Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, Fernández-Hernando C, and Suárez Y. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response”. Journal of Clinical Investigation, 2019.

27. Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán A, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, and Lamas S. “Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis.” JCI Insight, 2019. 

26. Malik S*, Rad AT*, Yang L, Oberoi-Khanuja TK, Nieh MP, Bahal R. “Universal Discoidal Nano Platform for Intracellular Delivery of PNAs.” Nanoscale, 2019. (*Both authors contributed equally)

25. Malik S, Bahal R. “Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for enhanced delivery of antimiR phosphorothioates in cancer cells in vitro.” Journal of Nanobiotechnology, 2019.

24. Seo Y-E, Suh H-W, Bahal R, Josowitz A, Zhang J, Song E, Cui J, Noorbakhsh S, Jackson C, Bu T, Piotrowski-Daspit A, Bindra R, Saltzman WM. “Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma.” Biomaterials, 2019.

23. Malik S, Asmara B, Moscato Z, Mukker JK, Bahal R. “Advances in Nanoparticle-based Delivery of Next Generation Peptide Nucleic Acids”. Current Pharmaceutical Design, 2019.

2018

22. Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In utero nanoparticle delivery for site-specific genome editing. Nature Communications, 2018.

21. Malik S, Oyaghire S, Bahal R. “Applications of PNA-laden nanoparticles for hematological disorders”. Cellular and Molecular Life Sciences, 2018.

20. Bahal R, Manna A, Hsieh WC, Thadke SA, Sureshkumar G, Ly DH. “RNA-Templated Concatenation of Triplet Nucleic Acid Probe” Chembiochem, 2018.

19. Bahal R*, Hsieh WC*, Thadke S, Bhatt K, Sobczak K, Thornton CA, Ly DH. “Design of ‘Mini’ Nucleic Acid Probe for Cooperative Binding of RNA-Repeated Transcript Associated with Myotonic Dystrophy Type 1”. Biochemistry, 2018. (*Both authors contributed equally)

2017

18. Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM. Anti-tumor activity of miniPEG-γ modified PNAs to inhibit microRNA-210 for cancer therapy. Molecular Therapy Nucleic Acids, 2017.

17. Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM “Therapeutic Peptide Nucleic Acids: Principles, Limitations, and OpportunitiesYale Journal of Biology and Medicine, 2017.

2016

16. Bahal R, McNeer NA, Quijano E, L Yanfeng, Sulkowski P, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, -Giráldez FL, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Saltzman WM, Ly DH, Glazer PM. In vivo correction of anemia in thalassemic mice by gPNA-mediated gene editing with stem cell factor treatment and nanoparticle deliveryNature Communications, 2016.
Research featured in the news (5 out of 29 news outlets): Mentioned in Faculty of 1000,The Washington Post, New gene-editing trick discovered just in time for J-Lo’s “CRISPR” TV series. 2016. Science Daily, Scientists edit gene mutations in inherited form of anemia. 2016. Bioscience Technology. Gene-editing Technology Cures Genetic Blood Disorder in Mice. 2016 ZME Science, Gene-editing technology successfully cures genetic disorder in mice – and it’s not CRISPR 2016.

15. Bahal R, Gupta A, Glazer PM, Saltzman WM. Polymer nanoparticles for delivery of Peptide Nucleic Acids (PNA). Journal of Controlled Release, 2016.

2015

14. McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Correction of F508del CFTR in airway epithelium using nanoparticles delivering triplex-forming PNAs. Nature Communications, 2015.
Research featured in the news: Yale News, Yale scientists use gene editing to correct mutation in cystic fibrosis. 2015. Lung disease news, Yale Researchers Effectively Correct Cystic Fibrosis Gene Mutation in Mice. 2015, Fierce biotech research, Yale collaborators use gene editing tech to fix a cystic fibrosis mutation. 2015. Cystic fibrosis news today, New strategies could correct genetic mutation responsible for cystic fibrosis, 2015.

13. Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumor microenvironment. Nature, 2015.
Research featured in the news: Yale News, Yale Researchers Develop Method to Attack Cancer at Its Source, Bill Hathaway, 2014. Beth Israel Deaconess Medical Center, microRNA Silencing Provides a Successful New Model for Cancer Therapeutics. 2014. Science Newsline. Team devises ingenious method to attack cancer at its genetic source. 2014. Recommended article in Faculty of 1000 (F1000) by Drs. Gabriele Varani, Yu Chen, K Mark Ansel.

12. Bahal R, Gupta A, Glazer PM. Precise genome modification using triplex forming oligonucleotide PNAs. In: Genome Editing: Next Step in Gene Therapy, 2015 (Editor, Dr. Mathew Hirsch, University of North Carolina).

2014

11. Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, Giráldez FL, Fields RJ, Saltzman WM, Ly DH, Glazer PM. Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition. Current Gene Therapy, 2014.

10. Delgado E, Bahal R, Yang J, Lee JM, Ly DH, Monga SPS. β-Catenin knockdown in liver tumor cells by a cell permeable gamma guanidine-based peptide nucleic acid. Current Cancer Drug Targets, 2014.

9. Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Modified Poly (lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Advanced Health Care Materials, 2014.

8. Manna A, Rapireddy S, Bahal R, Ly DH. MiniPEG-gPNA. PNA Protocol Methods Molecular Biology. 2014.

2013

7. Bahal R, McNeer NA, Ly DH, Saltzman WM, Glazer PM. Nanoparticles for delivery of antisense γPNA oligomers targeting CCR5. Artificial DNA PNA XNA, 2013.

2012

6. Bahal R, Sahu B, Rapireddy S, Lee CM, Ly DH. Sequence-unrestricted, Watson-Crick recognition of double helical B-DNA by (R) miniPEG-gamma PNAChembiochem, 2012.

5. Thomas SM, Sahu B, Rapireddy S, Bahal R, Wheeler SE, Procopio EM, Kim J, Joyce SC, Contrucci S, Wang Y, Chiosea SI, Lathrop KL, Watkins S, Grandis JR, Armitage BA, Ly DH. Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models. ACS Chemical Biology, 2012.
Research featured in the news: The Tartan online, Researchers create GPNAs to suppress tumor growth, 2012.

2009

1. He G, Rapireddy S, Bahal R, Sahu B, Ly DH. Strand invasion of extended, mixed sequence B-DNA by gammaPNAs. Journal of American Chemical Society, 2009.

Book Chapters

  1. Bahal R, Gupta A, Saltzman WM, Glazer PM. Nanoparticle-mediated delivery of peptide nucleic acids. Nanobiomedicine, M/s Stadium Press LLC, USA. 2014. 6, 223-245.
  2. Popli H, Bahal R, Gupta A. Advancement in parenteral drug delivery: Vital role of nanoparticulate systems. Nanobiomedicine, M/s Studium Press LLC, USA, 2014, 6, 382-409.
  3. Khanna S, Bahal R, Bharatam PV. 2006. In silico studies on PPAR gamma agonistic heterocyclic systems. In: Topics in Heterocyclic Chemistry, 2006, 3, 149-80.